 Stockard Channing as Abigail Anne Bartlet First Lady |
 Dulé Hill as Charlie Young Personal assistant to the president |
 Allison Janney as Claudia Jean "C.J." Cregg Press Secretary |
 Joshua Malina as Will Bailey Deputy Communications Director |
 Janel Moloney as Donnatella Moss Staff Assistant to Josh Lyman |
 Richard Schiff as Tobias Zachary Ziegler Communications Director |
 John Spencer as Leo Thomas McGarry Chief of Staff |
 Bradley Whitford as Joshua Lyman Deputy Chief of Staff |
 Martin Sheen as Josiah "Jed" Bartlet President of the U.S. |
Recurring/Past Cast
 Rob Lowe as Samuel Norman Seaborn Deputy Communications Director |
|
| Moira Kelly | Madeline "Mandy" Hampton |
| Kathryn Joosten | Mrs. Landingham |
| John Amos | Admiral Percy Fitzwallace |
| Timothy Busfield | Danny Concannon |
| Emily Procter | Ainsley Hayes | Lisa Edelstein | Laurie (a.k.a. Brittany Rollins) | Renee Estevez | Nancy | Melissa Fitzgerald | Carol |
| Jorja Fox | Secret Service Agent Gina Toscano |
| Tim Matheson | Vice President John Hoynes |
| Marlee Matlin | Joey Lucas |
| Elisabeth Moss | Zoey Bartlet |
| Suzy Nakamura | Kathy |
| Devika Parikh | Bonnie |
| NiCole Robinson | Margaret, Leo's secretary |
| Allison Smith | Mallory O'Brien, Leo's daughter |
| Kim Webster | Ginger |
| Mary-Louise Parker | Amy Gardner |
| Anna Deavere Smith | Nat'l Security Advisor Nancy McNally |